In POL, select Configure to enter the configuration screen and then click New in the bottom left to start the Virtual drive creator. Once installed, close and exit to the main POL menu.
If Wine x86 version 3.4 does not appear under "Installed Wine versions", then select it from the "Available Wine versions" window and click on the > in the middle to install it.
Wine x86 version 3.4 was used for this installation so check if it is installed by starting POL and then selecting Tools -> Manage Wine Versions.
Wine 4.15 requires the POL 4.3.4 update from the official POL repositories to be installed. The caveat is that there will be some issues with images, but should work fine 97~% of the time. To consider: Wine x86 version 4.15 is more stable than 3.4 (below), or 3.14 (GlasierXplor's post on POL Forum).
In which case Office will act normally (subjective) again. Office will start with a maximum size restricted to the top left of your primary display, and will refuse to respect the size of your desktop, until you connect the "correct" number of displays again.
It is uncertain whether installing these made any difference so you could try the manual installation steps below first and then come back to this step if you encounter errors. I received various errors relating to winetricks and mono from the scripts I tried previously so I had already installed these by the time I tried the manual installation.
Office 2016 Pro Plus link is the first one on that page.
Optional: download the Office 2016 installation file if you don't already have it or have a CD.